Heterogeneous perfusion is a consequence of uniform shear stress in optimized arterial tree models
- Author(s)
- Wolfgang Schreiner, Rudolf Karch, Martin Neumann, Friederike Neumann, Susanne M Roedler, Georg Heinze
- Abstract
Using optimized computer models of arterial trees we demonstrate that flow heterogeneity is a necessary consequence of a uniform shear stress distribution. Model trees are generated and optimized under different modes of boundary conditions. In one mode flow is delivered to the tissue as homogeneously as possible. Although this primary goal can be achieved, resulting shear stresses between blood and the vessel walls show very large spread. In a second mode, models are optimized under the condition of uniform shear stress in all segments which in turn renders flow distribution heterogeneous. Both homogeneous perfusion and uniform shear stress are desirable goals in real arterial trees but each of these goals can only be approached at the expense of the other. While the present paper refers only to optimized models, we assume that this dual relation between the heterogeneities in flow and shear stress may represent a more general principle of vascular systems. Π2003 Elsevier Science Ltd. All rights reserved.
- Organisation(s)
- Computational and Soft Matter Physics, Research Group Workflow Systems and Technology, Department of Statistics and Operations Research, Department of Economics
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Journal of Theoretical Biology
- Volume
- 220
- Pages
- 285-301
- No. of pages
- 17
- ISSN
- 0022-5193
- DOI
- https://doi.org/10.1006/jtbi.2003.3136
- Publication date
- 2003
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1030 Physics, Astronomy
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/c42e4478-6488-43db-a12b-9eb93a80a8cd