Bistability of Dielectrically Anisotropic Nematic Crystals and the Adaptation of Endothelial Collectives to Stress Fields

Author(s)
Georgios Stefopoulos, Tobias Lendenmann, Thomas M. Schutzius, Costanza Giampietro, Tamal Roy, Nafsika Chala, Fabio Giavazzi, Roberto Cerbino, Dimos Poulikakos, Aldo Ferrari
Abstract

Endothelial monolayers physiologically adapt to flow and flow-induced wall shear stress, attaining ordered configurations in which elongation, orientation, and polarization are coherently organized over many cells. Here, with the flow direction unchanged, a peculiar bi-stable (along the flow direction or perpendicular to it) cell alignment is observed, emerging as a function of the flow intensity alone, while cell polarization is purely instructed by flow directionality. Driven by the experimental findings, the parallelism between endothelia is delineated under a flow field and the transition of dual-frequency nematic liquid crystals under an external oscillatory electric field. The resulting physical model reproduces the two stable configurations and the energy landscape of the corresponding system transitions. In addition, it reveals the existence of a disordered, metastable state emerging upon system perturbation. This intermediate state, experimentally demonstrated in endothelial monolayers, is shown to expose the cellular system to a weakening of cell-to-cell junctions to the detriment of the monolayer integrity. The flow-adaptation of monolayers composed of healthy and senescent endothelia is successfully predicted by the model with adjustable nematic parameters. These results may help to understand the maladaptive response of in vivo endothelial tissues to disturbed hemodynamics and the progressive functional decay of senescent endothelia.

Organisation(s)
Computational and Soft Matter Physics
External organisation(s)
Eidgenössische Technische Hochschule Zürich, Eidgenössische Materialprüfungs- und Forschungsanstalt, Università degli Studi di Milano-Bicocca
Journal
Advanced Science
Volume
9
No. of pages
13
ISSN
2198-3844
DOI
https://doi.org/10.1002/advs.202102148
Publication date
03-2022
Peer reviewed
Yes
Austrian Fields of Science 2012
103015 Condensed matter
Keywords
ASJC Scopus subject areas
General Engineering, General Physics and Astronomy, General Chemical Engineering, General Materials Science, Biochemistry, Genetics and Molecular Biology (miscellaneous), Medicine (miscellaneous)
Portal url
https://ucrisportal.univie.ac.at/en/publications/956fc128-f485-4a56-870b-4a32675f0316