Structures and pathways for clathrin self-assembly in the bulk and on membranes
- Author(s)
- Richard Matthews, Christos N. Likos
- Abstract
We present a coarse-grained model of clathrin that is simple enough to be computationally tractable yet includes key observed qualitative features: a triskelion structure with excluded volume between legs; assembly of polymorphic cages in the bulk; formation of buds on a membrane. We investigate the assembly of our model using both Monte Carlo simulations and molecular dynamics with hydrodynamic interactions, in the latter employing a new membrane boundary condition. In the bulk, a range of known clathrin structures are assembled. A membrane budding pathway involving the coalescence of multiple small clusters is identified.
- Organisation(s)
- Computational and Soft Matter Physics
- Journal
- Soft Matter
- Volume
- 9
- Pages
- 5794-5806
- No. of pages
- 13
- ISSN
- 1744-683X
- DOI
- https://doi.org/10.1039/c3sm50737h
- Publication date
- 2013
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 103036 Theoretical physics, 102009 Computer simulation, 103029 Statistical physics
- Keywords
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/4e1ab1e1-17a9-4736-82c9-ec86da949365