Structures and pathways for clathrin self-assembly in the bulk and on membranes

Author(s)
Richard Matthews, Christos N. Likos
Abstract

We present a coarse-grained model of clathrin that is simple enough to be computationally tractable yet includes key observed qualitative features: a triskelion structure with excluded volume between legs; assembly of polymorphic cages in the bulk; formation of buds on a membrane. We investigate the assembly of our model using both Monte Carlo simulations and molecular dynamics with hydrodynamic interactions, in the latter employing a new membrane boundary condition. In the bulk, a range of known clathrin structures are assembled. A membrane budding pathway involving the coalescence of multiple small clusters is identified.

Organisation(s)
Computational and Soft Matter Physics
Journal
Soft Matter
Volume
9
Pages
5794-5806
No. of pages
13
ISSN
1744-683X
DOI
https://doi.org/10.1039/c3sm50737h
Publication date
2013
Peer reviewed
Yes
Austrian Fields of Science 2012
103036 Theoretical physics, 102009 Computer simulation, 103029 Statistical physics
Keywords
Portal url
https://ucrisportal.univie.ac.at/en/publications/4e1ab1e1-17a9-4736-82c9-ec86da949365