Development of novel methods to investigate soft and biological materials
The study of soft and biological systems requires methodological innovation to capture their multiscale complexity. The SoMeX Lab has pioneered the development of optical techniques, with a particular focus on Differential Dynamic Microscopy (DDM) and related approaches. These tools combine the advantages of scattering methods with the spatial resolution of microscopy, in a wide range of scattering wave-vectors, enabling experiments that would be difficult or impossible with standard light scattering techniques. Through ongoing refinements, we continue to push the boundaries of what is measurable, enabling novel insights into the dynamics of colloids, polymers, and biological assemblies. In addition to DDM, the lab is intensely active in developing novel rheomicroscopy tools. Rheomicroscopy, an innovative methodology that integrates traditional rheological measurements with high-resolution optical microscopy, enables the simultaneous assessment of a material’s macroscopic mechanical response and its microscopic structural and dynamic rearrangements, widening the scope of classical rheology.
- Stefano Villa, Paolo Edera, Matteo Brizioli, Veronique Trappe, Fabio Giavazzi, Roberto Cerbino (2022). Quantitative rheo-microscopy of soft matter. Front. Phys. 10, 1013805.
- Chiara Guidolin, Christopher Heim, Nathan B. P. Adams, Philipp Baaske, Valeria Rondelli, Roberto Cerbino, Fabio Giavazzi (2023). Protein Sizing with Differential Dynamic Microscopy. Macromolecules 56, 8290-8297
- Enrico Lattuada, Fabian Krautgasser, Maxime Lavaud, Fabio Giavazzi, Roberto Cerbino (2025). The Hitchhiker's Guide to Differential Dynamic Microscopy. The Hitchhiker’s Guide to Differential Dynamic Microscopy. arXiv preprint arXiv: 2507.05058.
- Nikolaos Kalafatakis, Roberto Cerbino (2025). ShearView: A Compact Stress-and Strain-Controlled Rheometer for Integrated Rheo-microscopy. arXiv preprint arXiv:2508.08951.
- Matteo Brizioli, Manuel Alejandro Escobedo-Sanchez, Patrick M McCall, Yael Roichman, Veronique Trappe, Margaret Gardel, Stefan U. Egelhaaf, Fabio Giavazzi, Roberto Cerbino (2025). One- and two-particle microrheology of soft materials based on optical-flow image analysis. Soft Matter, 21 1373-1381.